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What fraction of mammalian genomes is transcribed has been the subject of intense debate in the scientific literature as different genome-scale platforms have availed themselves to the question [ 1- 6].

The extent to which mammalian genomes are pervasively transcribed has been controversial; however, many of the questions revolve around whether the pervasive transcripts represent defined functional products or whether much of the detected RNA represents random transcriptional noise (van Bakel et al., 2010; Clark et al., 2011).

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Formerly discovered in Solanum tuberosum and Arabidopsis, TRIMs have been reported in monocots and dicots while LARDs, which were shown to be transcribed, have been reported in Triticeae [ 4, 6].

In Wilms' tumours, abnormally high levels of IGF2 mRNA and loss of imprinting (LOI) of IGF2, allowing both paternal and maternal alleles to be transcribed, have been observed (Reeve et al, 1985; Ogawa et al, 1993; Rainier et al, 1993).

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A correlation between early replication and actively transcribed regions has been previously established [ 19, 42].

DNA methylation within transcribed regions has been detected in about a third of Arabidopsis [ 77, 78] and rice [ 73, 79] genes.

A list of highly transcribed RNAPII genes has been obtained from the literature (Azvolinsky et al., 2009 and references therein).

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