We previously reported that AHR itself has prostate tumor suppressive functions in TRAMP mice; i.e., TRAMP mice in which Ahr was knocked out developed neuroendocrine prostate carcinomas (NEPC) with much greater frequency than did those with both Ahr alleles.
The offences stack up in this Lady and the Tramp variation, in which Drew Barrymore's pampered pooch gets lost in lawless Mexico and is almost coerced into dog fighting (which would have been a relief).
We employed the murine transgenic adenocarcinoma of the mouse prostate (TRAMP) model, in which prostate-specific expression of SV40 large T antigen results in prostate cancer (Greenberg et al., 1995), to evaluate the role of NR2F6 in cancer immunity.
A similar genetically modified rodent species is the 'TRansgenic Adenocarcinoma of the Mouse Prostate' (TRAMP) model, in which expression of the SV40 transforming sequences is targeted to the prostate by a prostate-specific rat probasin promoter (Greenberg et al, 1995).
The best characterized GEMs have been created using the androgen-dependent probasin promoter to determine tissue specific transcription of SV40 oncogenes: the transgenic adenocarcinoma of the mouse prostate (TRAMP) model in which the transgene includes large and small T antigen early SV40 oncogenes [ 29] and the LADY and the TRAP rat models, which express only the large T antigen [ 30, 31].
And there was "Lady or a Tramp," a Fox series in which "rude and crude" party girls were sent to finishing school a concept that, over two years, morphed into the Britishized show "The Girls of Hedsor Hall".
Davies – a wandering poet who railroaded his way across the US and Canada (where he lost a leg) and tramped around the UK for six years – paints a comparatively upbeat view of an England in which a tramp could depend on food and drink from generous strangers, and in which many doss houses offered bed and board indefinitely.
The filmfest ends next Friday, May 23, with "Lady and the Tramp II: Scamp's Adventure" (2001), in which the mischievous Scamp, son of Tramp and Lady, ventures far from home and meets Angel, a reluctant stray, and the collar-free Junkyard Dogs.
There, he made such pointed films as "Easy Street," set in a rough slum in which the Tramp defeats a fearsome brute and installs a reign of peace, and "The Immigrant," showing the Tramp's American dream tested by the horror of poverty.
