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Gene expression profiles revealed substantial differences in the trajectory of aging changes between female and male brains.
By simultaneously corroborating the classic results [8 10] and providing the first experimental evidence for the novel theory [2 4], our study resolves apparent contradictions in the study of aging and challenges the traditional paradigm by demonstrating that condition-environment interactions dictate the evolutionary trajectory of aging.
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The trajectories of aging that your parents and grandparents experienced are no longer relevant.
8 The concept of frailty is believed to help clinicians and researchers understand the heterogeneity and inequalities of health trajectories of aging and to offer practitioners useful tools for patient care.
Ultimately, we hope our findings will help identify a safe weight loss approach that can delay or prevent late life disability by changing the trajectory of age-associated functional impairment associated with obesity.
These differences among depots in the trajectory of age-related preadipocyte dysfunction may contribute to disproportional loss of subcutaneous fat.
However, results with respect to the impact of education on the trajectory of age-related cognitive decline have been mixed [ 50].
However, cross-sectional analyses hardly capture the rate and trajectory of age-dependent LTL shortening in an individual, as well as variations in these parameters among individuals.
As the choice to retain the oldest 2% of surviving females was based on human population data, and not informed by Drosophila biology, a cursory analysis of aging trajectories in the assay populations is merited.
New Zealand data suggests that direct extrapolation from trajectories of people aged 65 85 to people aged 85 and over is likely to be inaccurate, for example, in patterns of living circumstances, reasons for hospital admission and even in survival [ 30].
This implies differing trajectories of ageing for different individual brains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com