These include versions of two well-known spatiotemporal trajectory indexing techniques: the scalable and efficient trajectory index and Chebyshev polynomial indexing.
The confidence interval and trimmed mean of trajectory index are derived by bootstrapping analysis (B = 100).
The trimmed mean time evolution trajectory index is presented for the top three candidate temporal genes in each bone healing system.
Likewise, the statistical evolutionary trajectory index with statistical significance for zebrafish data is given in Supplementary Table 2, where we filtered out genes by coefficient of variation (CV) criteria remaining 12,034 genes.
Here, we discuss several methods that can be applied to model timecourse RNA-seq data, including statistical evolutionary trajectory index (SETI), autoregressive time-lagged regression (AR(1)), and hidden Markov model (HMM) approaches.
The autocorrelations of the residuals are computed by the sliding of all possible cases over the original time series, which are referred to as a trajectory index for given gene.
As the third real data application, to identify temporal dynamics, we have reanalyzed the third data, zebrafish embryonic transcriptome, focusing specifically on the identification and characterization of temporally differential expression using statistical evolutionary trajectory index and autoregressive time-lagged AR(1) model.
In " Time series expression analyses using RNA-seq: a statistical approach," S. Oh et al. apply three real datasets and simulation studies to demonstrate the utility of statistical evolutionary trajectory index, autoregressive time-lagged regression, and hidden Markov model approaches for RNA-seq datasets in temporal version.
We conduct all the emulations in the mobile scenario with trajectories indexed from 1 to 4 as shown in Figure 5.
For example, Alvarez et al proposed seven trajectory based indices which are suitable for fuzzy inference on real-time dynamic vulnerability [6].
