After a 2007 game in Denver, Pittsburgh Steelers safety Ryan Clark's spleen and gallbladder were removed as a result of complications from sickle-cell trait caused by the altitude.
The aetiology is unknown, although recent studies have found an autosomal recessive trait caused by mutations of the SLC34A2 gene in affected patients [16].
Rather, students think of a single process in which gradual changes in the trait, caused by the environment, occur over the entire species (Bishop and Anderson 1986 , 1990 also see results from statement 24; Table 2).
It is well known that dyslipidemia is a complex trait caused by multiple environmental and genetic factors and their interactions [2] [6].
It is possible that DNA methylation of disease-associated alleles may affect the relative risk of carriers to develop the trait, cause phenotypic heterogeneity or may explain some of the phenotypic differences in monozygous twins [44].
One is transmitted as an autosomal dominant trait caused by mutations in the RyR2 gene.
Treatment response is thought to be a complex trait caused by a combination of genetic and environmental factors.
In addition, dyslipidaemia is well recognized as a complex trait caused by multiple environmental factors and the interaction of genetic and environmental factors.
