Sentence examples for trail trail from inspiring English sources

Thus, more potent TRAIL death receptor-targeting reagents, such as oligomerized TRAIL, TRAIL fusion proteins with the capability to anchor to the cell surface or engineered TRAIL death receptor antibodies with high affinity for Fc γRIIb may have the potential to elicit improved anti-tumor activity, but this may come along with a risk for so far not recognized side effects.

HITTING THE TRAIL Trail Days runs from May 19 to 21.

Following the mud flats, the path continues along the banks of the Severn towards the River Wye with Chepstow Castle marking the end of the path but if you're feeling fit, there's a shortcut back to Prestatyn via the Offas's Dyke Trail trail - a mere 177 miles.

Consequently, diseases caused by each of these viruses are thought to be mediated, in part, by altered TRAIL: TRAIL receptor interactions.

Moreover, in animal models, interrupting TRAIL: TRAIL receptor signaling ameliorates CD4 T cell depletion of HIV infected PBL-NOD-SCID mice [7], acute liver injury following HBV transfection [8] and steatohepatitis following acute viral infection and alcohol use [9].

TRAIL, TRAIL R1 and TRAIL R4 were expressed by many of the cells expressing CD68 (macrophages).

We next examined the effect of inhibiting PI3K/AKT pathway on the expression of Bim, p27/Kip1, cyclin D1, TRAIL, TRAIL-R1/DR4 and TRAIL-R2/DR5.

Considering the ubiquitous expression of TRAIL receptors, the TRAIL-TRAIL receptor system might be involved in a variety of pathological conditions such as atherosclerosis.

Besides TRAIL, TRAIL-R1 or TRAIL-R2-selective variants of TRAIL and agonistic antibodies have been designed.

Interestingly, one study has reported enhanced expression of transmembrane TRAIL on the cell surface of circulating CD3+ and CD14+ cells after AMI and has documented the expression of two of the four transmembrane receptors for TRAIL, TRAIL-R1 and TRAIL-R2, in human cardiomyocytes [3].

Two other receptors for TRAIL, TRAIL-R3 (DcR1), which has no cytoplasmic death domain, and TRAIL-R4 (DcR2), which has an incomplete death domain, have also been identified.