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The smallest trail to date was in the village of Chalfont St Peter, Buckinghamshire, which had about 15 stalls.
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This hampers efficacy of TRAIL-based therapies and to date, the therapeutic benefit of TRAIL in clinical trials is indeed rather limited.
The sale of shares in the search engine Yandex last year was the second-biggest I.P.O. of an Internet company to date, trailing only Google's in 2004.
Messaging on social networks has to date trailed far behind cutting edge webmail services.
However, to date, TRAIL-receptor agonists have only shown limited therapeutic benefit in clinical trials.
Investigations to date have focused on the ability of TRAIL to induce apoptosis in cancer cells.
The Premier League champions are enduring their worst opening to a top-flight season in 29 years, having won only once in five games to date to trail Manchester City by 11 points, and confront Arsenal at Stamford Bridge on Saturday.
To date, Ford trails General Motors and Toyota in China and has a tiny presence in India.
Five TRAIL-receptors have been identified to date.
South America Inca Trail to Machu Picchu Marathon.
Trail to commute.
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