Sentence examples for trail signalling from inspiring English sources

Overexpression of E6 was shown to protect colon cancer cells from death receptor-induced apoptosis by affecting the stability of the DISC, indicating a functional link between the presence of E6 and TRAIL signalling.

To determine the role of TGF-β-Activated Kinase-1 (TAK1) in TRAIL signalling, we analyzed the effects of adding TRAIL to mouse embryonic fibroblasts (MEFs) derived from TAK1 conditional knockout mice.

The effects of NF-κB and JNK on TRAIL signalling are controversial, with some reports showing that their activation protects cells from TRAIL induced apoptosis [17] and others suggesting the opposite effect [18].

Greater levels of caspase-8 activation were achieved using the dual treatments as TRAIL signalling occurred concomitantly with cFLIP downregulation.

However, in recent years the functional role of caspase-10, especially in TRAIL signalling, has been contested.

One inhibitor of the TRAIL signalling pathway is FLIP, which structurally resembles caspase 8 and can act as an inhibitor of apoptosis when highly expressed in certain cancers.

TRAIL signaling provides another level of complexity compared with CD95L signaling because TRAIL binds to two death receptors TRAIL-R1 and TRAIL-R2 as well as to several decoy receptors.

These results revealed that accumulated active caspase-3 by proteasomal inhibition can trigger apoptotic cell death in TRAIL signaling, whereas the death domain-containing TRAIL receptors expressed by VSMCs do not cause apoptotic cell death, even though TRAIL ligation induces caspase-3 activation.

TRAIL signaling mediates T-cell- and natural killer (NK) cell-dependent metastasis suppression in xenografts [6] [9].

The mechanism by which activation of TRAIL signaling induces reductions in HIV viral load is uncertain.

To address this question, we constructed isogenic tumor cell lines that are functional for both TRAIL and FasL signaling, inhibited for both or inhibited for just TRAIL signaling.