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In animal tests TRAIL kills tumor cells but spares most healthy ones.
Recently, it was shown that TRAIL kills malignant glioma cells through induction of apoptosis, providing a new therapeutic strategy for these tumors [36] [38].
Altogether, iz-TRAIL kills melanoma cells by activating the extrinsic apoptosis pathway involving caspase-8, -3 and PARP cleavage.
Thus, it is possible that anti-tumor CD8 T cells use IFN-γ and TRAIL to kill tumor cells.
It is thus expected that secreted soluble TRAIL should kill a larger number of cells through wider distribution.
However, inhibition of the endogenous Bak antagonist Mcl-1 enables TRAIL to kill cells via Bak.
In contrast, phagocytosis of apoptotic cells by DCs fails to induce maturation and causes tolerance to tumor antigens by generating helpless CD8+ T cells that produce TRAIL to kill activated T cells.
B4 Trail of Killing in Bronx The bodies of four relatives and the fiance of one victim, ages 14 to 39, were found in three buildings.
Setting aside the sheer terror of the dictator's Gulag, torture programs, rapes of Berlin and the Eastern Bloc -- barbaric even by World War II's horrific standards -- there is no end to Stalin's murderous trail, including killing off the Catholic leadership in Poland and exterminating masses of Jews.
His third-quarter chop block on a Titans defender in the end zone resulted in a safety; his third-quarter fumble at the Titans' 5-yard line with the Giants trailing, 19-10, killed a crucial drive.
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