Sentence examples for trail in combination from inspiring English sources

To determine whether apoptosis was involved in TRAIL-induced cell death, we examined apoptosis induced by TRAIL in combination with SH122, with Annexin V-FITC and PI staining by flow cytometry analysis.

The combined effect of both drugs was tested using 50 ng/ml TRAIL in combination with bortezomib at several concentrations below the IC50 value.

Importantly, our data also show that the synergistic effects of the death ligand TRAIL in combination with either ER stressors or DNA damaging anti-cancer drugs are nearly exclusively mediated via an increased activation of Bid-induced apoptosis signaling.

They also show that the synergistic effects of TRAIL in combination with either ER stressors or genotoxic anti-cancer drugs are nearly exclusively mediated via an increased activation of Bid-induced apoptosis signalling.

Briefly, CI-values >1 indicate a synergistic effect of TRAIL in combination with a pharmacological inhibitor.

We performed ligand affinity precipitations using Flag-tagged TRAIL in combination with M2 beads (Sigma).

Smac knockdown had also been shown to suppress apoptosis in melanoma cells, when induced by TRAIL in combinations with UVB or a potassium channel inhibitor.

Western blot analysis confirmed the potent apoptogenic effect of iz-TRAIL in combination with SMAC-mimetics as compared with the single agents, and that the dimeric SMAC-mimetics are more powerful than the monomeric one in synergising with TRAIL.

Following identification of mitoxantrone and mithramycin as potential TRAIL sensitizers, we investigated the effect of different TRAIL concentrations in combination with a single dose of these sensitizer drugs.

Consequently, TRAIL therapy in combination with TNFα/IFN-γ-producing CTL adoptive transfer immunotherapy effectively suppressed colon carcinoma metastasis in vivo.

Consistent with an important contribution of TRAIL in NK-cell-mediated killing, the addition of soluble TRAIL-R2 in combination with anti-DNAM-1 reduced killing to an even greater extent, with more-robust reductions seen in UL141-expressing targets when compared to control cells (∼11-fold versus ∼4.5-fold).