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We have also demonstrated that the addition of an isoleucine zipper to the N-terminal of TRAIL greatly enhanced the trimerization of the fusion protein and dramatically increased its anti-tumor activity.
Remarkably, although most of these agonists alone were relatively inefficient triggers of apoptosis in HepG2 cells, pretreatment with TRAIL greatly sensitized cells to apoptosis induction by these mitochondrial triggers.
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Surfaces of the trails greatly and these may require differing tread designs.
Trails range greatly in difficulty: The novice should start with easy or medium trails.
All false trails can greatly decrease HTS success rates, since typically only a limited number of hits can be pursued.
Covering the bare mineral, compacted soil on skid trails thus greatly reduces surface runoff and sediment yield.
"The foot trail experience is greatly diminished when you're walking on a dirt road in the sun as opposed to walking on a trail under a canopy," said Peter Bauer, executive director of the Residents Committeee to Protect the Adirondacks, a nonprofit group.
The top numbers here still greatly trail behind the blue-chip success of the male masters; at the same Sotheby's sale that de Lempicka achieved her top price, Egon Schiele broke his world record with a £24,681,250 bid, achieving the third highest sale of the year so far.
Similarly, another M1 differentiation marker, TRAIL was also greatly upregulated in response to combination treatment.
We believe this arises due to poorly understood radio scattering characteristics of the meteor plasma, especially in light of recent work showing that plasma turbulence and instability greatly influences meteor trail properties at every stage of evolution.
Such impacts are often associated with trail widening and braiding that greatly expands the zone of damage beyond a narrow travel corridor.
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