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Exact(5)
In addition, as FRET can be performed in a small number of cells, we can also consider the possibility that this approach could provide a useful predictive information to the physician as concerns the susceptibility to TRAIL-mediated therapy or the possibility to booster TRAIL effects by using specific drugs able to modulate TRAIL-receptor recruitment into lipid rafts (e.g. perifosine, edelfosine).
When the LY30 and TRAIL effects were combined, our inability to simulate the observed dynamics of caspase-8 suggested an error in the model.
Thus, combination therapy with other drugs will be required, for example, for sensitization of apoptotic pathways or suppression of potentially protumoral TRAIL effects, to achieve major and lasting tumor remissions.
The TRAIL effects were adapted from a previously published model (Albeck et al., 2008b), and the LY30 effects were approximated from our previously published experiments on LY30 (Poh and Pervaiz, 2005; Poh et al., 2007; Shenoy et al., 2009).
To verify the hypothesis that factors modulating angiogenesis might, in addition, influence tissue factors related to tumour progression, we studied TRAIL effects upon tissue remodelling and invasiveness gene expression in different glioblastoma cell lines.
Similar(55)
Indeed, recursive average based on signal level induces phase shifting and trail effect on target.
The time constant for fast recursive average can be determined in order to allow an efficient fast perturbations filtering while not inducing significant trail effect.
Therefore, the remaining thickness of approximately 4.2 nm (=7 to 2.8 nm) is coming from the trail effect of the SIMS depth profile.
This is due to the trail effect and surface roughness of W BE, as we can see from the depth of 57 to 65 nm (or approximately 7 nm) of the 184 W depth profile.
Wohlwend's rainbow trail effect was added as a scarf or cape (which later became a rainbow burst behind the player), and the scoring mechanics were refined to reward players who took risks by letting the skier fly through the air without touching the screen.
Peak of TRAIL effect occurred at 24 h.
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