Sentence examples for trail blocked from inspiring English sources

Inhibition of TRAIL at this time point had no effect, but at later time points, dominant-negative TRAIL blocked the apoptosis of cells that repopulate the lumen later in morphogenesis.

Although previous studies investigated the contribution of the ligand TRAIL to Smac mimetic-induced apoptosis and demonstrated that knockdown of TRAIL, TRAIL-blocking antibodies or TRAIL receptor decoy constructs that sequester TRAIL were all unable to afford protection against Smac mimetic-induced apoptosis, our present study particularly addressed the role of TRAIL receptors.

Conversely, TRAIL blocks OPG-mediated inhibition of osteoclastogenesis.

HGS-ETR1 binding was specific for TRAIL-R1 as only soluble TRAIL-R1-Fc protein, but not other soluble TRAIL receptors, blocked binding.

Meso-TR3 bound avidly to endogenous MUC16, identical to soluble mesothelin itself and triggered a robust death pathway that involved the same signaling pathways as conventional TRAIL does (blocked by soluble DR5-Fc and global caspase inhibition with Z-VAD-FMK).

TRAIL-R2-Fc completely blocked TRAIL-induced apoptotic cell shedding in the carcinoma cell line HT29, confirming that death receptor-mediated apoptosis was responsible for the cell shedding induced by TRAIL treatment.

Thus, knockdown of Myc prevents CMS sensitization to TRAIL by blocking the decrease in FLIPL levels, which ultimately inhibits generation of active p18 caspase-8.

TRAIL receptor blocking antibodies were used to determine the relative contribution of each individual DR to IFN-γ induced sensitization to rhTRAIL in SW948-TR.

These results suggest that TRAIL may directly bind to DR5 as transmembrane protein and is therefore spared from the inhibitory actions of the TRAIL-blocking antibody.

You'll see not only the usual flurry of quantifiable activity points, rebounds, assists, improbable trailing blocks in finely timed bunches but also those motions and habits that make James memorable as a personality as well as a player.

The day after we arrived, I cut up the trail-blocking spruce with a chain saw and also turned a couple of smaller trees -- one poplar and one spruce that had been toppled by storms the previous year -- into firewood to fuel both the fireplace and the woodstove.