Sentence examples for trail agents from inspiring English sources

Additionally, it is important to elucidate the molecular components that determine TRAIL-receptor preferences in order to be able to select the best TRAIL agents to potentially treat pancreatic cancer and other tumour types in the future.

Therefore, introducing in the in vivo studies promising synergistic to TRAIL agents such as Quercetin that have been proved efficient in vitro in our lab (Psahoulia et al, unpublished data) may lower cytotoxicity by reducing even more TRAIL concentrations leading to more efficient targeted therapies.

APDC, YC-1 and MG-132 were confirmed as novel TRAIL sensitizing agents whilst the FDA-approved agent, Bortezomib, demonstrated caspase-8-dependent TRAIL-sensitization at 5 nM.

These include (i) the use of recently developed highly active TRAs, (ii) the addition of efficient, but cancer-cell-selective TRAIL-sensitizing agents to overcome TRAIL resistance and (iii) employing proteomic profiling to uncover resistance mechanisms.

In search of novel yet non-toxic TRAIL sensitizing agents, numerous studies have focused their attention on natural agents that could potentiate TRAIL-mediated apoptotic effects at physiologically attainable concentrations.

The library contained altogether 32 2.55%) potential caspase-8-dependent, TRAIL sensitizing agents, of which five were termed as "potent" compounds due to observed killing of all three cell lines, based on the criteria described above.

On her trail is Agent 47, a brutal force of death with a barcode on his shaved head.

In sum, we demonstrate the development of a 384-well HTS that allows identification of TRAIL-sensitizing agents acting specifically through the caspase-8 apoptotic pathways.

Thus, our cells are a suitable model system for the identification of novel TRAIL-sensitizing agents acting through the caspase-8 axis.

Similar studies by other investigators utilizing a renal cell carcinoma model to search for TRAIL-sensitizing agents [17] have also demonstrated that novel agents of this class can be identified by such a strategy.

By screening the LOPAC library using this assay, we identified five known and two previously undescribed TRAIL-sensitizing agents that are confirmed with concentration-dependent curves produced from cell viability measurements.