Sentence examples for trail administration from inspiring English sources

Although c-FLIPS protein expression was undetectable before TRAIL administration in these two cell lines, its expression was drastically increased in cells that survived TRAIL treatment.

Thus, pretreatment with BAPTA-AM (5 or 10  μM, 30 min), followed by treatment with TRAIL (200 ng/ml, 3 h), resulted in a tremendous decrease in survival of NSCLC cells, indicating that blockage of Ca2+/calmodulin signaling significantly reduces survival of NSCLC cells in response to TRAIL administration due to pronounced downregulation of c-FLIPS.

Keeping in mind the few observations that the calmodulin level is significantly higher in lung cancers and its level correlates with the hystopathological grading and tumor staging, we inhibited Ca2+/calmodulin signaling and were able to demonstrate its involvement in the stability of c-FLIPS protein and survival of NSCLC cells in response to TRAIL administration.

When c-FLIP inhibition (FLIPi) was combined with TRAIL administration, a significant TRAIL-dependent kill was observed for all of the breast cancer cell lines tested, demonstrating a marked sensitization to TRAIL in resistant cell lines, but no more than an additive effect of FLIPi in the TRAIL-sensitive MDA-MB-231 cell line.

As Mr. Romney outlines on the campaign trail, his administration would veer sharply from this strategy.

Binding of TRAIL, or administration of agonistic antibodies to DR4 or DR5, resulted in receptor oligomerization and initiation of apoptosis via recruitment of membrane-proximal caspases (caspase 8 or caspase 10).

In conclusion, the senescence secretome may sensitize both premalignant cells and certain TRAIL-resistant tumors upon chemotherapy, thus providing a rationale for the co-administration of TRAIL or TRAIL pathway-activating therapeutics.

While harsh and, at times, inflammatory rhetoric about immigrants has emerged on the 2016 presidential campaign trail, a senior administration official said the raids had "nothing to do with the caterwaulings of any member of the political class".

Two and a half years after punching her name into the campaign Web site, she goes to work every day at the Old Executive Office Building across the street from the White House, applying her computer expertise and the organizational skills honed on the trail to the administration's mammoth hiring process.

Criticism of China for reportedly stealing American jobs and livelihoods through unfair trade as well as adding to the United States record trade deficit, has spread from Congressional hearing rooms to the presidential campaign trail, forcing the administration to send senior officials to Beijing in recent weeks to figure out where China was willing to bend and how to craft a compromise.

There are opportunities here to learn about trail maintenance, surveying, administration and wildlife management.