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The transport protein particle (TRAPP) complexes are involved in the tethering process at different trafficking steps of vesicle transport.
SNAREs seem to mediate membrane fusion in all of the trafficking steps of the secretory pathway.
These data suggest that Staufen does not play a role in the early trafficking steps of osk transport, but rather in the terminal stages of transport.
On the other hand, Clarke et al. [17] and Melke et al. [18] proposed the models for the Smad nucleocytoplasmic shuttling and Smad phosphorylation response to the TGF-β signal without considering the receptor trafficking steps.
Together these studies suggest that aSyn causes defects in multiple vesicle trafficking steps.
CT might be handed off to other molecules for further trafficking steps.
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This summer the Algerian government moved to stop petrol trafficking, stepping up the tension on its border with Morocco's Oriental province.
Rab4b would thus act on a trafficking step which does not involve the classical endosomal recycling, but specifically concerns the GLUT4-sequestration compartment.
These findings suggest that the impact of GPCR self-association on the trafficking of individual protomers or dimers may differ depending on the particular receptor and trafficking step involved.
Each of these subgroups represents a distinct conserved trafficking step.
The trafficking step across this space remains mysterious[ 207, 208].
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