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Further, DCs but not macrophages can cross-present antigen of apoptotic cells to T cells because they express αvβ5 integrin, which plays a critical role in the trafficking of exogenous antigens [31], [32].
Trafficking of exogenous Tac and Tac-FCHO1 fusion proteins in HeLa cells.
PI3K activation also appears to interfere with cell surface trafficking of exogenous NIS as well as all-trans retinoic acid-induced endogenous NIS.
Another disease featuring tau phosphorylation in cerebellar neurones is Niemann Pick disease where defects in the intracellular trafficking of exogenous cholesterol causes neurodegeneration.
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We also evaluated the traffic of exogenous LDL-[BODIPY-Cho] in infected macrophages isolated from LL biopsies (Virchow's cells) by confocal analysis.
This indicates that similar defects exist for retrograde traffic of both exogenous sterols we tested.
Our results shed light on processes of exogenous mRNA trafficking, which are crucial to estimate the mRNA bioavailability, and increase the biosafety of transgene integration mediated by transposition.
Thus, cell surface trafficking of both endogenous and exogenous NIS were decreased by PI3K activation.
Ricin, along with several protein toxins have been exploited for their intracellular trafficking and/or membrane translocation properties allowing delivery of exogenous peptides directly into the MHC class I processing and presentation pathway of target cells (1- 4).
Next, we examined the effect of exogenous ARF6-GTP on Ctx trafficking in NPC fibroblasts.
A similar inhibitory effect of PI3K activation on NIS surface trafficking and function was observed upon forced expression of exogenous NIS.
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