Sentence examples for trafficking intact from inspiring English sources

Thus the addition of TIMP-1 may inhibit pathological CD4+ T-cell entry into the brain during multiple sclerosis for example, while leaving effector CD8+ T-cell trafficking intact for responses to pathogens.

To monitor receptor trafficking, intact HA-GnRHR transduced HeLa cells were incubated 0 60 min at 37°C with mouse anti-HA (1 200) in DMEM with 2% fetal calf serum with or without 10−7 M GnRH, and the incubations were terminated by washing the cells (1×) in ice-cold PBS.

In Figure 7, the AA scheme has an unstable total transmission success rate because we assume that the real network will not keep traffic intact and we sophistically make a little change in the numbers of the four messages transmitted by the MS to reflect the behavior of a real network.

However, the lysosomotropic agents did not completely block receptor degradation in lysosomes, suggesting that the trafficking of intact eGFP NPRA also occurred through a lysosome-independent pathway.

However, it has recently been suggested that several GPCRs self-associate transiently on the cell surface [12], [13], [14], raising the possibility that such GPCRs might not traffic as intact dimers or oligomers.

gM expressed without gN remained diffusely perinuclear, consistent with retention in the endoplasmic reticulum, even when all its cytoplasmic trafficking motifs were intact.

While receptor-mediated endocytosis for EGF was intact, trafficking of EGF to lysosomes and/or lysosomal degradation of EGF appeared to be defective in CP-r cells.

Because intact trafficking is critical for both EGFR localization to the leading edge and for the chemotactic response to EGF gradients (van Rheenen et al, 2007), we predicted that NAV3-depleted cells would aberrantly respond to a chemotactic cue.

Future studies of CB1R trafficking in more intact systems may help to develop our understanding of how membrane proteins are preferentially localized to distinct domains of astrocytes and how they influence local cell signalling.

An important feature of these proteins is the tendency to vary their toxin domains through a process of recombination that might replace an existing toxin domain by a distinct one encoded by standalone cassettes, while retaining the rest of the protein's architecture (i.e. parts related to trafficking and delivery) intact.

In the presence of the inhibitor BFA compartments appeared and both processes were strongly inhibited, suggesting that an intact intracellular trafficking system is required for their execution (Fig. 11 and Figure S3).