Analysis of this group revealed enrichment in genes involved in 'intracellular protein traffic' (p-value = 3.7e-6) and 'cell cycle' (p-value = 8.4e-6) when analyzed for biological process GO terms (Huang et al., 2008, 2009).
We then performed a functional analysis (Table S8) and we found enrichment in Cell proliferation and differentiation (P<0.001), Protein metabolism (P = 0.004), Cell cycle (P = 0.002), Signal transduction (P = 0.01), Intracellular protein trafficking (P = 0.02), and mRNA transcription (P = 0.02).
This cluster of genes was analyzed by IPA (Additional file 2) and results suggest immune response processes and connective tissue disorders, such as immune cell trafficking (P = 0.021), acute phase response signaling (P <0.001) or cell-mediated immune response (P = 0.005).
For a particular traffic load, P nb and P hd can be evaluated as follows: {P}_{mathrm{nb}}=frac{B_{mathrm{nb}}}{A_{mathrm{nc}}} (2) {P}_{mathrm{hd}}=frac{D_{mathrm{nh}}}{R_{mathrm{ha}}} (3).
where D n is the delay constraint for the non-realtime traffic, and P r and P n are the packet loss rate threshold for the realtime and non-realtime traffics, and A r and A n are the maximum packet aggregation number for the realtime and non-realtime traffics.
The classes overrepresented included membrane traffic proteins (p < 0.001), RNA/DNA-binding proteins (p < 0.001), cytoskeletal structural proteins (p < 0.001), and enzymes (p < 0.01).
LTL decreased in association with age in both traffic officers (p = 0.01) and referents (p = 0.001), but traffic officers had shorter LTL within each age category.
Seven independent PM sources were identified by PCA: steel (Pb, Zn, Cd, Mn) and pigment (Cr, Mo, Ni) manufacture, road dust (Fe, Ba, Cd), traffic exhaust (P, OC + EC), regional-scale transport (NH+4, SO2−4, V), crustal contributions (Al2O3, Sr, K) and sea spray (Na, Cl).
After the shipping ban went into effect in October 2005, the declining trend continued at a slower but significant rate of a 2.5% average monthly traffic decline (p = <0.0001).
Coles notch in either ear was found in 63% of the male railway maintenance workers, exposed to noise levels of 75to9090 dB(A), compared with 53% of the non-noise exposed (<70 dB(A)) traffic controllers (p < 0.001).
