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Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal.
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Inhibition of PI3-kinase or Akt caused an aberrant accumulation of Ebola virus particles in intracellular vesicles, indicating a role of the PI3-kinase-Akt pathway in vesicular trafficking of virus particles [54].
To investigate the presence of the intracellular trafficking of virus particles, sections of TB40/E-infected HCECs (figure 4A D) or HFFs (figure 4E, F) were analysed under an electron microscope.
Hence, the profound effect of double depletion of Rabs 5 and 11 on virus production likely reflects the involvement of these two Rabs in the sequential trafficking of virus glycoproteins through this network and suggests that the virus exploits the normal trafficking of PM in its envelopment strategy.
Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5.
Therefore, the axon to myelin traffic of the virus took place in the absence of axonal degeneration in Wlds mutant mice.
This study was designed to investigate the trafficking of Andes virus (ANDV) and Sin Nombre virus (SNV) glycoproteins and to determine if ANDV or SNV glycoproteins G1 and G2 could be substituted for each other while still retaining normal trafficking.
Overexpression of DN Rab5 and DN Rab7 mutants that result in constitutive inactivation of endosome biogenesis has been widely used to study trafficking pathways of viruses within the vesicular compartment [55], [56].
Trafficking of Hantaan virus (HNTV) and SNV glycoproteins has been studied and conflicting results were published regarding the Golgi targeting of G1 and G2 when expressed individually.
However, there is dearth of knowledge in regards to trafficking of a virus via endosomes.
Such glycoprotein: receptor interactions function in attachment and binding at the cell surface, successive internalization (uptake into the host cell), membrane fusion, and trafficking of the virus [ 1].
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