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Li, Z. & Murthy, V. N. Visualizing postendocytic traffic of synaptic vesicles at hippocampal synapses.
Several transporters fundamental for the traffic of synaptic vesicles were also expressed differentially in the Igf1−/− cochlea, which is consistent with previous observations of aberrant synapsis at the inner hair cells [17].
Indeed, Aβ peptides are generated by the proteolytic cleavage of a transmembrane precursor (the amyloid protein precursor, APP) (Ref. 15), PrP is a membrane protein anchored in the external leaflet of the plasma membrane by a glycosylphosphatidylinositol anchor (Ref. 16), and α-synuclein is involved in the traffic of synaptic vesicles (Ref. 17).
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Polarized trafficking of synaptic proteins to axons and dendrites is crucial to neuronal function.
In this case, the kinesin motor family contributes to the trafficking of synaptic vesicles (Bloom, 2001).
Seizure‐induced trafficking of synaptic GABAA and glutamate receptors may in part explain the development of time‐dependent pharmacoresistance.
This in turn affects the trafficking of synaptic vesicles upon endocytosis during prolonged stimulation (Verstreken et al., 2005).
To more directly test how TC10DN and TC10CA affect the trafficking of synaptic AMPARs during LTD, we induced LTD by low-frequency synaptic stimulation (Montgomery and Madison, 2002; Montgomery et al., 2005).
Further studies identified VAB-8 and UNC-14 as direct binding partners and substrates of UNC-51 [ 25, 26], two proteins involved in the axonal trafficking of synaptic vesicles and endosomal trafficking of the axon guidance receptor UNC-5.
NSF (N-ethylamide sensitive factor) is a key protein associated with a myriad of processes in the central nervous system including trafficking of synaptic vesicles and regulation of neuronal glutamatergic, GABAergic, adrenergic and muscarinic membrane receptors [ 34].
Akt1 signaling has also shown to be essential for AMPA receptor trafficking in hippocampal neurons, further supporting a role for Akt1 in trafficking of synaptic proteins (Qin et al., 2005b; Hou et al., 2008; Pratt et al., 2011).
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