Mechanisms that govern stem cell trafficking, including mobilization and homing to damaged tissues It is known that stem cells are endowed with migratory potential and that they are released from their niches in a process known as mobilization.
It will also deal with molecular mechanisms involved in stem cell pluripotency, quiescence, proliferation, and differentiation and will cover mechanisms that regulate stem cell trafficking, including their mobilization into peripheral blood and homing to damaged tissues.
Recent studies have shown that CXCR4, CXCR7 and their ligand, CXCL12, are important for the regulation of leukocyte mobilization and trafficking.
(2) Individual and combined actions of the principal stress hormones, norepinephrine (NE), epinephrine (EPI), and corticosterone (CORT), in mediating mobilization or trafficking of specific leukocyte subpopulations.
The experiments described here were designed to elucidate the: (1) Time-course, trajectory, and subpopulation-specificity of stress-induced mobilization and trafficking of blood leukocytes.
CXCR4 plays a role in fetal development, trafficking of naïve lymphocytes, mobilization of hematopoietic stem cells, migration of several types of neural cells, and synaptic transmission [16], [17].
Physiologically low concentrations of suPAR are involved in neutrophil trafficking and stem cell mobilization.
This suggests that distinct mechanisms may be responsible for the recruitment of each population and argues against a generalized alteration in marrow-derived cell mobilization or trafficking.
SuPAR is expressed at low levels under physiological conditions in human blood and it has a known role as a circulating protein involved in neutrophil trafficking and stem cell mobilization [ 21, 22].
Although F4/80lo/CD11bhi macrophages are not completely dependent on CCR2 for mobilization and trafficking to tissues, the data suggest the action of CSF1-Fc on monocyte-derived rather than resident macrophages is the critical step promoting hepatic enlargement.
