Sentence examples for traffic defects from inspiring English sources

Membrane traffic defects might cause cell integrity defects.

We hypothesized that these strains could be defective for delivery and/or retention of the major K+ transporter, Trk1, at the plasma membrane because of the membrane traffic defects, although our previous studies demonstrated that this was not the case for the arl1Δ mutant (Munson et al., 2004a).

This corrector rescues F508del-CFTR from its abnormal intracellular localization to the cell surface, a traffic defect shared by all Class II CFTR mutants.

Our aim here was to assess efficacy of lumacaftor on other CFTR mutants with the same traffic defect as F508del (Class II (Amaral and Farinha, 2013)).

apy-1 mutant worms abnormally accumulate intestinal autofluorescence, which has been interpreted as a lysosomal traffic defect also associated with aging (U ccelletti et al. 2008).

Although ∆lam4 has no sterol traffic defect, this might be explained by its lower level of expression compared to Ysp2p, so the previous results suggest that transposon insertion in LAM4 can produce a dominant negative effect.

Pharmacologic restoration of the trafficking defects of HERG missense mutations has been documented.

Restoration of rpm-1 function in presynaptic neurons does not rescue the GLR-1 trafficking defects of rpm-1 mutants.

A possible explanation for this discrepancy is tissue-specific differences in the relationship between Notch trafficking defects and Notch activity.

Expressing α-syn in these mutant cells, especially aged cells, exacerbates these trafficking defects and leads to aberrant α-syn trafficking, ROS accumulation and cell death.

This study indicates that multiple molecular mechanisms, including gating abnormalities, trafficking defects, or a combination of both, are responsible for SCN5A-related familial SSS.