The effect of pH variability in the gastrointestinal tract environment on the dissolution of the polymeric enteric coating was investigated using the Monte Carlo method.
Formulation into nanoparticles can improve drug stability in the harsh gastrointestinal (GI) tract environment, providing opportunities for targeting specific sites in the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the GI tract.
Larger studies are needed to fully evaluate the genital tract environment both in the absence and following coitus.
Cultivation in urine partly mimics the urinary tract environment, and identification of differentially expressed genes in vitro may therefore represent a potential means to identify novel fitness factors required for this particular ecological niche.
The latter phenomenon is likely to be a reflection of adaptation to oral and respiratory tract environment rich in glycoproteins and murein polysaccharides which previously was proposed to contribute to the pathogenic potential of pathogenic streptococci [36], [37].
Oxygen electron paramagnetic resonance (EPR) imaging technique showed that the GI tract environment fluctuates between anaerobic and microaerobic conditions [ 14].
