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Another potential intervention is selective oral and/or digestive tract decontamination (SDD/SOD).
Once in the GI tract, decontamination or removal can be challenging, and perforations of the drug container can be fatal.
The ICU does not use selective digestive tract decontamination, but chlorhexidine oral gel is used as part of the VAP prevention bundle.
Patients did not receive selective digestive tract decontamination.
Selective digestive tract decontamination using antibiotics in the oral cavity or whole gastrointestinal tract decontamination have been shown to reduce rates of VAP and mortality [ 42, 43].
The separate meta-analyses involving digestive tract decontamination by antibiotics showed lower efficacy as compared to respiratory tract decontamination by antibiotics.
Similar(31)
ante noctem, dd daily dose, ICU intensive care unit, SDD selective decontamination of digestive tract, TDM therapeutic drug monitoring Ref. [23].
Selective decontamination of digestive tract (SDD) regimens are more effective than prophylactic regimens that include single antifungal drugs in reducing yeast colonisation, invasive yeast infection, and in-hospital mortality.
negative, SDD selective digestive tract decolonization, SOD selective oral decontamination, MU million units, f/u follow-up, MIC minimal inhibitory concentration aDecolonization regimens were applied four times daily via oral route or nasogastric tube unless otherwise stated as dose per day (/d).
Selective decontamination of the digestive tract (SDD) reduces the risk of respiratory tract infections.
The 28-day mortality rate was 27.5% for the control group, 26.9% for the oral selective decontamination of the digestive tract group, and 26.6% for the systemic selective decontamination of the digestive tract group (P < 0.05).
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