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"Tracking Progression of Patient State of Health in Critical Care Using Inferred Shared Dynamics in Physiological Time Series," Lehman LH, Nemati S, Adams RP, Moody GB, Malhotra A, Mark RG, Proceedings of the 35th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013.
We conclude that monitoring microglia activation and microgliosis at prepathological stages might be a powerful tool for detecting the onset and tracking progression of neurodegenerative disease.
It also appears to increase with chronic kidney disease stage and severity suggesting a role in tracking progression of chronic kidney disease [ 49].
The plan also aimed at tracking progression of the disease in 1.2 million HIV infected persons by the end of 2008.
Despite the excitement about recent advances in the identification of AD-related biomarkers, neuropsychological assessment remains a critical component of evaluation to ensure a cognitive correlate of biomarker abnormalities and to assist in detecting and tracking progression of early AD.
Other investigations demonstrated that erosions on radiographs were evident on MRI a median of 2 years earlier [ 3] and that MRI could be a superior tool for tracking progression of RA in patients [ 4]. Brown and colleagues [ 5] recently showed that evidence of inflammatory activity on MRI persists despite the appearance of clinical remission.
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Biomarkers are proteins or other molecules that can help diagnose or track progression of disease; one example is prostate-specific antigen, the biomarker used to detect prostate cancer.
Weekly assessment of weight and fur was performed to track progression of the UCMS syndrome (as in [ 39]).
Performance is relatively stable across repeated test sessions, hence the task is suitable for longitudinal designs such as those used to track progression of neurodegenerative pathology [5].
It identified illness clusters for further investigation, tracked progression of the epidemic in the United States, and facilitated specimen collection from suspect and probable case-patients for SARS diagnosis.
Ultimately the greatest utility of biomarkers may be in the preclinical stages of AD, to identify and track progression of the disease prior to significant cognitive impairment, at the point when disease modifying therapies are likely to be most efficacious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com