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We applied our methylation dynamics model to an RRBS dataset tracing the differentiation of adult HSCs (Bock et al., 2012).
In addition, we extended the results of the earlier studies [ 18, 33] by identifying Li-7 cells as an HCC line capable of tracing the differentiation of CD13 CSCs and for testing the effects of drugs on CD13 CSCs.
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For example, the lineage tree shown in Figure 1 traces the differentiation of adult hematopoietic stem cells (HSCs) through several intermediate states into different terminally differentiated blood cell types.
One such application is to develop lineage-specific reporter lines to trace the lineage differentiation of hESCs.
The identification and differentiation of strains of Mycobacterium tuberculosis by DNA fingerprinting has provided a better understanding of the epidemiology and tracing the transmission of tuberculosis.
Tracing the outbreak.
Furthermore, we employed inhibitors of ionotropic glutamate receptors to evaluate whether glutamate signaling is involved in NG2+ cell-fate/differentiation pathways by tracing the fates of the extended yellow fluorescent protein (EYFP -positive cEYFP -positived evidencellsggesting thandglutamate receptors play a role in the normal development ofound
In vitro live cell tracking to trace the dynamic changes of differentiation toward neuronal fate by miR-124a would have also inform us when we can expect the probable changes of cellular fate after in vivo administration despite the difference between in vitro and in vivo situation.
In this study, neuron-specific pTα1 promoter-driven RFP reporter system was adopted to trace the activation of neuronal differentiation in vitro and in vivo induced by the administration of exogenous miR-124a in the implants of neural progenitor or stem cells.
The neuron specific alpha1 tubulin promoter-driven RFP reporter (pTa1-RFP) was used to trace the miR-124a-induced neuronal differentiation in live cell condition.
Molecular phylogenetic analyses have revealed that these variants share a common monophyletic origin that can be traced back before the differentiation between protostomes and deuterostomes, very early in metazoan evolution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com