Tracing microsatellite alterations in follow-up sera of patients with different cancer entities and investigating their clinical significance has previously been described in several studies [ 27, 28].
Through proteomics it has been possible to establish that certain diseases can be traced from alterations of certain proteins in plasma [ 2].
CREBITEL thesaurus facets include "Material", "Evidence of Technique, Mark and Trace", "Alteration", "Intervention" and "Investigation Methods".
Due to these unique properties, urothelial tumours provide a good model for the clonal analysis and chronological tracing of genetic alterations in human cancer.
Still, the common thread uniting many of the SCNT failures can be traced to epigenetic alterations, specifically failures in chromatin remodelling and DNA and histone methylation [ 13, 43, 44].
By examining more samples from each patient using array-CGH with a higher resolution, we should be able to draw a more detailed genetic tree and pedigree for multifocal urothelial tumours and trace the genetic alterations that accumulate during their development.
Although the mechanical properties of wood suffer quite early in the decay (Winandy and Morrell 1993), it is difficult to trace the chemical alterations related to the mechanical ones because they are too small to be detected with conventional and standardised wet-laboratory methods.
Figure 1 depicts a representative tracing of beat-to-beat alterations in developed force (Fdev).
Given the demonstration of mitochondrial UC dysfunction by enzymology, stable isotopic tracing was employed to assess alterations in ureagenesis.
Thus, Se may act as an antitumoural agent although more studies are needed to investigate the actual role of antioxidants and their possible relationships with trace elements alterations in the pathogenesis of breast cancer (Bock et al, 1991; Gerber et al, 1996).
