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An ideal PSMA-targeted PET tracer show a delayed urinary excretion with a slight shift towards hepatobiliary clearance, which is especially important for the detection of primary PCa and the early pattern of lymph node metastasis.
Blends as a tracer show a strong enhancement in diffusion in comparison to the pure dPS tracer, indicating that the intradiffusion coefficient measured in a sample where there is no chemical gradient is much bigger than the tracer diffusion measured from a thin film of pure dPS.
While unrestrained proliferation has been described as a hallmark of cancer and is a target of several targeted anti-cancer therapeutics, due to differences in blood thymidine levels and in the metabolism of FLT, both uptake and excretion of this tracer show significant differences in biodistribution in different species.
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The tracer showed a normal biodistribution ex vivo and a moderate stability in vivo.
NEURON TRACER showed that the length of osteocyte processes was 0.26 ± 0.02 μm per 1 μm3 bone compartment.
A diffusion study using deuterium as an isotopic tracer shows that the Si/OSG interface is the main diffusion path.
As a result, the tracer showed a rapid (<15 min) elimination in urine accompanied by a slower excretion via the hepatobiliary route.
Using carcinoembryonic antigen (CEA) as model analyte, the designed tracer showed linear range from 0.02 to 5.0 ng mL−1 with the detection limit down to 6.7 pg mL−1.
[18F]5-OH-FPPAT, an aminotetraline tracer, showed promising results in rats and monkeys [20], but no evaluation in humans has been published so far.
Challenge tests using Rhodamine WT tracer showed that membrane log removal value decreased to 3.5 after three scaling cleaning cycles, which corresponded to a pinhole size of 0.06 μm2 on the FO membrane.
The tracer showed a weighted blood half-life t 1/2 of 17.1 min (Additional file 1: Figure S6), a typical pharmacokinetic profile for small molecules, which matches up with values obtained for other Olaparib derivatives [2, 23].
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