This accounts for the secretion of trace amounts of functional FVII molecules, which could trigger the enzymatic amplification pathway of coagulation.
One possible explanation for the genetic complexity is the diffusion of trace amounts of functional protein from surrounding heterozygous tissues into the gametes [ 36, 37].
To build templates without any prior knowledge of the catalytic mechanism, the Evolutionary Trace Annotation (ETA) (Kristensen et al., 2006; 2008) server heuristically selects residues based on Evolutionary Trace (ET) predictions of functional sites in protein structures (Lichtarge et al., 1996).
In the cedar aphid C. cedri, a deep association has been formed between S. symbiotica and B. aphidicola, with the former now being a co-obligate intracellular endosymbiont with a highly reduced genome size of only about 30% of that of a free-living Serratia, deprived of mobile elements and with more than half of its genome showing no traces of any functional sequence.
For a certain class of positive, continuous, decreasing, and convex functions F we show the convexity of trace functionals of the form tr(F(H+U−ε(U)))−ε(U), where U is a bounded, self-adjoint operator and ε(U) is a normalizing real function the Fermi level which may be identical zero.
We refer to the solid and trabecular components as structurally less differentiated, but would emphasise that these are part of a papillary carcinoma spectrum and are completely different from the undifferentiated (anaplastic) carcinomas of the thyroid, which lack any trace of structural or functional thyroid differentiation.
This approach to trace the evolutionary origin of functional domains in the human proteome facilitates better understanding of their functional versatility as well as provides insights into the functionality of hypothetical proteins present in the human proteome.
Therefore, we adopted a complementary approach to trace the dominant modes of functional connectivity change within the EC in a fully data-driven manner (Haak et al., 2014) (see 'Materials and methods').
The Results section now reads as follows: Therefore, we adopted a complementary approach to trace the dominant modes of functional connectivity change within the EC in a fully data-driven manner (Haak et al., 2014; see Methods).
We found ten such commonly enriched GO terms and traced back their branch of functional groupings to identify the originating parent GO terms.
