Sentence examples for tpa form from inspiring English sources

The data presented here establish that, in vivo, endogenous neuroserpin and tPA form a regulatory circuit in the brain that significantly affects seizure progression.

27, 30– 32 In this study, we demonstrate that neuroserpin and tPA form a regulatory circuit in the murine CNS that influences seizure progression via tPA-mediated PDGFR α signaling and control of the BBB.

The chemical facilitated unscrolling of MWCNT and subsequent bridging with terephthalaldehyde (TPA) to form 3D-hierarchical BRG nanoconstruct exhibited synergistic effect by combining enhanced electrical properties and facile chemical functionality for stable bio-interface.

Whereas TPA measures formed plaques, IMT can be measured where no focal disease is present.

When this anticoagulated plasma was clotted with thrombin, in the presence of calcium ions and low concentrations of tPA, clots formed and then lysed rapidly under the influence of plasmin, whereas if tPA was left out of the reaction, clots were stable for hours (compare turbidity profiles 3 and 1 in Fig. 4B).

Only tPA-V formed oligomers spontaneously, and elicited a higher IgG2a anti-V antibody response in immunized mice, suggesting increased TH1 type cellular immune response.

A relatively inactive form of tPA was constructed by conjugating tPA with low-molecular weight heparin followed by complexation with albumin-protamine conjugate, termed 'camouflage'camouflage

The proteolytic plasminogen/plasmin function of tPA cleaves the precursor forms of neurotrophins to the active forms of these trophic factors, e.g. proteolytic activity by tPA converts proBDNF and proNGF in the ECM to active trophic factors, respectively [48] [50].

Orth and colleagues [ 37] confirmed that tPA, under its free form or complexed to PAI-1, binds to LRP-1 to be intracellularly degraded.

When released, it can be rapidly converted into its two-chain form (tc-tPA) by plasmin present at the cell surface or in solution.

In the current study, ~50% of the tPA was expressed in the soluble form, which represents the first report of soluble tPA expressed using a prokaryotic expression system.