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Similarly, the development of Arafat's final symptoms, and his death from a blood condition known as disseminated intravascular coagulation, or DIC, was "compatible with an acute toxin pathology, possibly the radiosotope polonium-210".
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Although the presence of such an undiscovered toxin in the pathology of bovine enterotoxemia cannot be excluded, it is unlikely because type A strains originating from bovine enterotoxemia cases as well as from healthy cattle and other animal species are capable of inducing lesions in an intestinal loop model [ 10].
However, the details of the interaction between mitochondrial toxins, progression of pathology, and α-syn aggregation are not fully established.
One of the primary mechanisms through which toxins may promote CNS pathology is by inducing inflammatory immune factors.
Kidneys are the principle excretory organs for vertebrates and excessive or chronic exposure to exogenous toxins can lead to renal pathology and renal failure.
The lack of DA neuron loss in most gene-based PD animal models and the dearth of α-syn pathology in most toxin-based PD animal models underscore a crucial role of gene environment interactions in PD.
Human exposure to the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin
Corynebacterium diphtheriae produces diphtheria toxin, which is responsible for the systemic pathology associated with diphtheria, whereas Vibrio cholerae produces cholera toxin, which is responsible for the diarrheal pathology associated with cholera.
However this double-toxin induced model solely represents striatonigral-like pathology, without reproducing oligodendroglial inclusion pathology, mediating secondary neuronal multisystem degeneration [3].
Previous studies have reported associations between neuronal pathology and exposure to such toxins.
"These processes result in major differences in toxin composition, and these different toxins cause different pathologies or levels of toxicity when they are injected, and they also undermine antivenom treatment," Casewell said.
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