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Toxin information can be browsed through dynamic trees, and each toxin has a dedicated page summarising all available information about its sequence, structure, and biological activity.
This new ontology allows for the first time the retrieval of spider toxin information based on a precise definition of toxin specificity.
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While florfenicol is a described reproductive toxin this information has largely been obtained from classical mammalian laboratory toxicity tests.
With respect to their removal in water treatment procedures, of the more than 60 microcystin congeners, microcystin-LR (L, L-leucine; R, L-arginine) is the best studied cyanobacterial toxin, whereas information for the other toxins is largely lacking.
The effect of CSPG4 was only specific to TcdB, as HeLa/CSPG4−/− cells behaved the same as wild-type cells in terms of toxin-induced cell rounding, Rac1 glucosylation, and cell death after exposure to TcdA, a closely related C. difficile toxin (Supplementary information, Figure S5).
Assessing the human health risk associated with exposure to water-borne pathogens and toxins requires information on the susceptibility of individuals in the target population.
Evolution of resistance to synthetic toxins may present information relating to how organisms respond to naturally occurring chemicals in the environment (Scott et al. 1998).
Better understanding of these complexities will enable a greater understanding of how plant cells respond to toxins and key information about cellulose synthesis [ 6].
However, as with other toxins, the only information known about this interaction is that the BtR175 binding site of Cry1Aa is near loops 1, 2 and 3 [ 25, 26].
As well as being a member of the most well-studied dinoflagellate genus of PSP toxin-producers, for which a wealth of physiological and biosynthetic information on toxin production is available, A. minutum is an appropriate model for toxin production studies because of its simple toxin profile.
CDI: Clostridium difficile infection; IPC: Infection prevention and control; AIC: Akaike's information criteria; tcdA: Toxin A; tcdB: Toxin B; cdtA: Binary toxin; IRR: Incidence rate ratio; CI: Confidence interval; n: Number of isolates.
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