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Obtaining the histopathological pictures of the knee joints was performed by Dr. Bettina Lawrenz, Toxicological Pathology, Bayer HealthCare AG, Wuppertal, which is gratefully acknowledged.
Further data on the effects on the histopathology and enhanced images are available online in the "Toxicological Pathology Atlas of Small Laboratory Fish" (RIVM 2004).
Advice on how to contact pathologists can be gained via veterinary pathology departments in universities, toxicological pathology societies [STP (www.toxpath.org); ESTP (www.eurotoxpath.org); BSTP (www.BSTP.org.uk)] or industry contacts.
Following sacrifice, multiple tissues (lungs, spleen, liver, kidneys, heart, stomach, intestine, testes, and ovary) were examined using standard toxicological pathology criteria and no toxicity was associated with fisetin treatment.
Moving these issues forward requires the development of a toxicological pathology atlas for fish to help better classify and understand the importance of such observations [for broader discussion of the value of fish histopathology, see Au (2004); Maack and Segner (2003); van der Ven et al. (2003)].
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The novel PhysioTel™ Digital M11 telemetry implant was evaluated in socially housed monkeys with respect to both safety pharmacological cardiovascular (arterial blood pressure (BP), heart rate (HR) and electrocardiogram (ECG)) and toxicological (clinical pathology and histopathology) endpoints.
Two truckloads of the dead birds arrived at the state's wildlife pathology laboratory near Albany today for toxicological tests.
Clinical pathology evaluations therefore assist in establishing toxicological dose response relationships in the preclinical safety assessment of a test article.
Gross pathology and histopathology exhibited no differences of toxicological significance between control and treated rats.
The nomenclatures produced by the toxicological pathologists represent the distillation of many years of pathology experience and so offer a robust route for recognising common lesions.
Combined exposure assessment may be of particular interest for certain groups of chemicals if the chemicals produce similar pathology or if they act on a similar mechanistic pathway or toxicological end point.
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