Sentence examples for toxicokinetic processes from inspiring English sources

Bioaccumulation and biotransformation are key toxicokinetic processes that modify toxicity of chemicals and sensitivity of organisms.

Toxicokinetic processes occurring after internalization must be considered prior to impution or measurement of concentrations at sites of toxic action.

We do not differentiate between passive and active uptake and elimination mechanisms, but assume, as an approximation, first-order kinetics for all toxicokinetic processes and that biotransformation products were formed from parent compounds in separate, independent pathways.

For example, in the EPA Guidelines for Carcinogen Risk Assessment (EPA, 2005), the toxicokinetic processes that lead to formation of the active agent or its distribution to the target tissue are considered in estimating dose, but they are not considered as part of the mode of action.

The model proposed herein can be used as a generic framework in which adjustments/modifications can be made to incorporate additional toxicokinetic processes that may be specific to particular POPs (e.g., diffusion limitation, plasma or tissue protein binding) if relevant for a lifetime scale in humans.

The variability in the toxicokinetic process makes interpretation of biomonitoring data inherently complex.

These four complex steps of absorption, distribution, metabolism, and excretion (ADME) make up the toxicokinetic process after a pesticide contacts and enters the body (Klaassen 2001).

The toxicokinetic process is complex and dynamic and may vary based on demographic variables such as age, sex, or race/ethnicity or may change with diet, coexposures (e.g., environmental chemicals, alcohol, tobacco, and medications), and certain medical conditions.

However, the in vivo toxicity of anti cholinesterase mixtures may deviate from concentration addition if the individual chemicals in a mixture interact via toxicokinetic or toxicodynamic processes to produce either antagonistic or synergistic effects (Borgert et al. 2004).

Attention will be paid to the main processes of the pharmacokinetic or toxicokinetic phase in drug action, including absorption, distribution and elimination (biotransformation and excretion).

Physiologically based toxicokinetic (PBTK) models can improve the understanding of the underlying mechanisms bioaccumulation processes and reduce uncertainty of regulatory decision in the future.