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Two novel schedules, involving irinotecan or oxaliplatin on day 1 with bolus FU/LV on days 2 5, were withdrawn from the NCCTG N9741 after excessive gastrointestinal and haematological toxicity, with a total of 10 toxic deaths among the first 108 patients treated (Morton et al, 2001).
Compound 12b exhibited high antitumour activity and low toxicity with a therapeutic index (TI) of 47.55.
Adamantyl derivative, 43, presented the lowest toxicity, with a higher TC50 and TI values than Lianbizhi.
Therefore, it is difficult to initiate the tigecycline therapy and bone marrow toxicity with a single-dose adjustment.
WPC PDT showed lethal toxicity with a drug dose above 50 mg/kg ALA at 1.6 J/cm2.
The size of nano-TiO2 particles may affect their toxicity, with a trend of increasing toxicity being associated with larger nano-TiO2 particles.
As for the algae, BLM v.0.0.0.17, underestimated the toxicity with a factor of 2.5 to 9.3, being significant in three out of four lakes (Table 2).
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To simplify the results of our data, toxicity was divided into three levels: a: no toxicity with an equivalent concentration below zero; b: low toxicity with an equivalent concentration ≤ 0.02 mg/L; and c: moderate toxicity with an equivalent concentration > 0.02 and ≤ 0.1 mg/L.
In contrast, Cu-loaded particles displayed significant toxicity with an IC50 of approximately 100 μg/mL (Figure 4A).
The acute toxicity assays of 2b proved its low acute toxicity with an LD50 value of 1551.71 mg/kg, and no toxicity reaction appeared at dose of 1200.00 mg/kg.
The HL-2 extract was the most effective one in protecting cells against SNP-induced toxicity with an EC50 (effective concentrations) of 31.31 μg/mL, followed by WV (EC50 = 49.35 μg/mL), and HL-1 (EC50 = 84.72 μg/mL).
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