Most patients had adjuvant treatment (RT/CRT), which increased toxicity.
Exogenous expression of miR-26a, 98, and 101 all led to significant toxicity in C666-1 cells, which increased with the addition of IR, whereas overexpression of miR-26b had no effect.
9 Further, it should be noted that elderly patients with renal dysfunction are particularly susceptible to developing high concentrations of digoxin, with an increased risk of cardiac toxicity, which consequently increases the mortality risk.
However, combination chemotherapy containing CDDP has significant toxicities, including severe nausea, vomiting and renal toxicity requiring adequate hydration, which increases the difficulty in the treatment of the elderly or outpatients.
It was found that the presence of nanoparticles in aqueous solution leads to the formation of reactive oxygen species, primarily hydroxyl radicals [33], which increases their toxicity.
This confirms the conclusion of Porcel et al. (2014) and Mc Mahon et al. (2011) who stipulate that the effect of nanoparticles is due to the confinement in nanometer size volumes of the electronic perturbation and ROS production, which increases the toxicity of radiation.
Renal insufficiency also impairs the excretion of some DMARDs, which increases (nonrenal) toxicity.
Along with the neurotoxic effect, pyrethroids may induce oxidative stress which increases the toxicity of the insecticide [ 15].
The REACH legislation requires that all chemicals produced over 1 ton/year are tested for hazardous properties such as toxicity and allergenicity [ 5], which increase the demand for accurate assays with predictive power for hazard identification.
