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The experiments in HCT-116 tumor-bearing mice showed that oral administration of propolis at doses that caused no detectable toxicity was associated with a decrease in mitotic cells and an increase in endoreduplications, increased p53 and decreased Ki-67 expression of cells in tumor sections.
In similar studies by the same group, Smith et al. [18] determined that copper-mediated Aβ toxicity was associated with an intermolecular bridge involving histidines 6, 13, and 14 of Aβ.
No toxicity was associated with any regime (data not shown).
Chemotherapy-induced toxicity was associated with improved overall and progression-free survival.
However, in contrast to H2O2, PQ toxicity was associated with a dramatic oxidation of cysteine residues.
The toxicity was associated with increased intracellular ROS production which is very similar to our findings here [ 29].
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These molecular features of DM1-associated RNA toxicity were associated with high mortality, growth retardation and muscle defects (abnormal histopathology, reduced muscle strength and lower motor performances) (Huguet et al., 2012).
The susceptibility of freshwater fish to the toxic effects of exposure to silver ions (Ag+) is well documented and acute toxicity is associated predominantly with ionic Ag+ interactions at the gills, where they inhibit basolateral Na+/K+-ATPase activity.
Some of this toxicity is associated with the widely acclaimed method of minimum tillage.
This toxicity is associated with high concentrations of reduced iron (Fe2+) in the soil solution.
Aluminum toxicity is associated with alteration of calcium metabolism in the brain [9].
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