In addition to selecting an appropriate initial antimicrobial regimen, optimal dosing, interval of drug administration, and duration of treatment are required for antimicrobial efficacy, limiting toxicity, and to prevent the emergence of bacterial resistance [ 21].
Dose‐limiting toxicity is defined as toxicity unacceptable enough to prevent an increase in dose or undesirable toxicity.
Patients who went off treatment before the fifth administration of cisplatin for reasons other than the evaluated toxicity were excluded from analysis of that toxicity, in order to prevent under-reporting of toxicity.
Divers who breathe oxygen fractions greater than of air (21%) need to be trained in the dangers of oxygen toxicity and how to prevent them.
Perhaps, the most effective way to approach the blocking of Aβ toxicity would be to prevent the formation of neurotoxic Aβ oligomers [ 3, 14].
Virostatic combinations involving HU and didanosine have been shown to be clinically effective [ 27– 29] but toxicity concerns continue to prevent wider usage.
Since dicoumarol does not cross the blood-brain barrier, the potential exists for human brain tumors to be destroyed with halogenated dimethylquinones and for peripheral host toxicity to be prevented by coadministration of dicoumarol.
Incubation of E. coli and pH-adjusted, desferrioxamine-treated CB07 resulted in nearly complete bacterial killing in triplicate experiments (Figure 5B), suggesting that ferric iron and other metal cations mentioned above are not mediating CB07-induced toxicity or that the concentration of DFO was insufficient to prevent toxicity.
Ascorbate has been shown to increase Cr VI) reductive activation, enhance toxicity, and potentiate mutagenicity, suggesting that ascorbate, commonly used as a redox scavenger to prevent toxicity of other environmental agents, is not suitable for counteracting Cr VI) toxicity (Salnikow and Zhitkovich 2008).
