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Exact(18)
Compared to the high risk of TAK-875 induced liver toxicity, there was no significant adverse effects such as hepatic and renal toxicity were observed in the chronic toxicity studies of compound 20 even at the higher dose.
Thus, despite moderate drug-related toxicity, there was no significant effect on pharmacodynamic or surrogate risk biomarkers.
"There was very limited evidence for reproductive and developmental toxicity; there was almost nothing".
If there was further symptomatic grade 4 haematological toxicity there was a further dose reduction, to 50% of starting dose.
Apart from slightly worse haematological toxicity, there was no significant difference in outcome or toxicity between age groups.
Thus, under conditions associated with reduction of oxaliplatin toxicity, there was no significant reduction in the concentrations of oxaliplatin-derived platinum in the plasma or dorsal root ganglia.
Similar(42)
In the specific case of developmental toxicity there is lack of knowledge of the mechanisms of toxicity.
Although each toxic peptide has its own unique features and kinetics of toxicity, there are striking similarities between these different transgenic lines, including common genetic modifiers and clear age-associated pathology.
Due to their toxicity, there is an obvious need to determine them at trace levels.
Until then, following the withdrawal of the only effective treatment, sodium arsenite pesticide which was withdrawn in 2001 because of its toxicity, "there's nothing to be done".
In view of improved life expectancy, sociocultural changes and better supportive measures for chemotherapy-induced toxicity, there is an increasing request for the administration of chemotherapy in elderly.
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