Sentence examples for toxicity testings from inspiring English sources

In laboratory tests with aqueous media containing NPs, the freshwater amphipod Hyalella azteca is exceptionally well suited for bioavailability and toxicity testings due to the epibenthic lifestyle, short life cycle, and sensitivity for environmental chemicals [41].

Combining the best software (including Hartung's) produced a consensus computational model that "performed just as well as the animal tests", says Nicole Kleinstreuer, who coordinated the exercise and develops alternative toxicity-testing methods for the US National Toxicology Program in Durham, North Carolina.

EOGRTS design makes toxicity testing progressive, comprehensive, and efficient by assessing key endpoints across multiple life-stages at relevant doses using a minimum number of animals, combining studies/evaluations and proposing tiered-testing approaches based on outcomes.

At the same time, new toxicity testing initiatives have arisen because of concerns for the humane use of animals and the failure of conventional animal-based toxicity studies to keep pace with evaluation of the large number of chemicals in commerce and new chemical products coming to market (NRC 2007; Safety Evaluation Ultimately Replacing Animal Testing 2012).

Toxicity: many TOXIC.

Mainly two statistical designs are performed: the point-estimation approach to compute the ECx (effective concentration for an effect of x%) as toxicity parameter and the hypothesis-testing approach to determine the NOEC (no-observed effect concentration).

When testing in animals is required for risk assessment, key aspects are studies along OECD-testing guidelines with "enhanced" study designs addressing additional endpoints such as reproductive toxicity and a developmental screening test to derive health-based tolerable drinking water limits with a limited number of animals.

This evidence of chronic toxicity is in contrast to the current safety-testing regime that is limited to an LD50 assessment over a few days.

In the short term, it is recommended that in vitro assays of nanomaterial toxicity should be confirmed by trypan blue exclusion, but there is an urgent need for the development of improved testing-based label-free approaches for measuring nanotoxicity in living cells.

No toxicity.

Therefore, the hypothesis-testing approach has been increasingly criticised during the past decade, so that OECD and ISO decided on a phasing-out of the NOEC as toxicity parameter, which at this point appears to be not followed unequivocally.