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The numerous studies reporting neuronal toxicity for different soluble Aβ oligomers support the conclusion that multiple soluble Aβ oligomer species exhibit neuronal toxicity, rather than a single, discrete toxic species.
Under our experimental conditions, surface coating had more impact on toxicity rather than on biodistribution of the AuNPs.
Hence, cytotoxicity itself is not promising evaluation method for toxicity rather than particles individual characterisation using antioxidant and bioactivity analysis.
Thus, the required non-clinical safety studies are characterized as those detecting off-target toxicity rather than on-target toxicity.
Sørensen et al. (2015) concluded mortality to be a more appropriate endpoint than immobility, in order to account for toxicity rather than physical restriction.
Evidently, the glucose modification of the cytotoxic agents increase human toxicity rather than increase the efficacy of the drug, which contrasts with published preclinical results [97].
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This may be explained by a weekly assessment of hematological toxicities, rather than the addition of cetuximab to TPF regimen.
The sample sizes for cohort expansions were based on the observation of latent (post-DLT period) toxicities rather than pre-planned statistical considerations.
The clinical relevance of increased exposure to sirolimus PK for patients with cancer receiving i.v. temsirolimus pertains to the potential for increased incidence or severity of toxicities rather than efficacy concerns.
The OMB has criticized by environmental groups for instructing the EPA to use existing toxicity data rather than require companies to conduct tests to determine if chemicals and pesticides can hurt humans, reports the New York Times.
Shorter incubation times of <24 hours for CPE development could be more suggestive of a toxicity problem rather than of virus induced CPE.
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