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These stable and toxic hetero-oligomers most probably cause toxicity over a longer period of time which is another important risk factor for the pathogenesis.
Whether this complex displays toxicity over a long time span should be studied further.
The biotic ligand model provides a quantitative framework for assessing metal toxicity over a range of hardness, pH and dissolved organic carbon (DOC) levels.
Twenty-eight patients were assessable for toxicity (over a total of 76 cycles— Table 3).
The cosmetic toxicity over a long term was not mentioned by the authors.
At least three patients in a cohort must have been assessable for toxicity over a 4-week period once grade 2 toxicity was reached.
Similar(48)
Consistent with the idea that PrPc at least partly mediates aggregated A β toxicity, over-expression of PrPc appeared to confer specific sensitivity to A β toxicity, since both the PrPc expressing and empty vector containing cells were similarly sensitive to the oxidizing agents dithiodipyridine (DTDP) and diamide, both of which have previously been shown to induce apoptosis.
3. Inhibition by toxicity: Over-expression of hundreds of genes has been shown to cause toxicity [ 22] and [ 23]; the mechanism of toxicity is not known for most of these genes.
Subcutaneous injection of the PoLigel-LA blend caused no local or systemic toxicities over a four-week period while the PoLigel-LCl caused immediate local toxicity.
Enrolment of patients was planned to continue as phase III if arm B showed advantages in efficacy and/or toxicity over arm A in the randomized phase II.
In addition, grantees of the CLARITY-BPA program (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) are collaborating on a GLP-compliant toxicity study over a wide range of administered BPA doses in rats.
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