Importantly, sub-optimal MEK or AKT inhibition in combination when compared with maximal MEK and AKT alone did not cause more growth inhibition in both HUVEC and Ker-CT cell lines, suggesting no additional toxicity once MEK or AKT is completely inhibited if a second inhibitor is added.
Cholesterol levels there seem to affect the synthesis of beta-amyloid proteins, their clearance from the brain, and their toxicity once plaques are established.
Patients were considered evaluable for response and toxicity once therapy was initiated.
To determine if puffer fish maintained toxicity once they were removed from the putative toxin source, we kept puffer fish in captivity.
As pointed out, owing to their metal toxicity once de-chelated, it is highly unlikely that manganese, gadolinium and other lanthanides will have opportunities for clinical translation.
Dose delays or discontinuation occurred for hematological and non-hematological toxicity; once resolved, TMZ was resumed without making up lost doses.
Given that scFvs are not prone to cytosolic aggregation, the lack of correlation between the spheroplast and periplasmic levels of scFv may be explained by differential toxicity once in the periplasm.
The characterization of the size and stability of C60 nanoparticles in suspension is very important to evaluate their toxicity once particle size can change during the preparation of the suspension, dilution, and exposure [ 11].
A subsequent study showed that a modified 5-FU schedule combined with 85 mg m−2 but with reductions of both oxaliplatin and 5-FU for haematologic toxicity once again reducing the oxaliplatin dose, was associated with marked reduction in efficacy in the second line setting – 12% in 37 patients but with a remarkable 72% response rate in 25 first-line patients (Cheeseman et al, 2002).
During the exposure period, clinical symptoms, including but not limited to changes in behavior, activity, skin, fur, excretions, mortality, and other clinical signs of toxicity, were observed once a day, and body weight was weighed weekly.
