Sentence examples for toxicity on day from inspiring English sources

Dose reductions of oxaliplatin were instituted for grade ⩾3 haematological toxicity (on day of treatment) and grade 3 peripheral neuropathy or grade 2 neuropathy persisting between cycles.

A treatment delay due to persistence of haematological toxicity or grade >1 non haematological toxicity on day of recycling occurred in 18 and 11 patients in PET and ET arm, respectively.

In case of haematological toxicity on day 8 (ANC<1.5 × 10 l−1, PLT<100 × 10 l−1), the gemcitabine treatment of day 8 was delayed for 1 week.

In case of persistent haematological toxicity on day 15, the gemcitabine day 8 treatment was omitted and chemotherapy was repeated on day 21 with a 25% dose reduction for both drugs.

The dose of gemcitabine on day 8 was reduced to 50% in case of neutrophils between 0.5 and 1.5 × 10 l−1, platelets between 50 and 100 × 10 l−1 or grade 3 nonhaematologic toxicity on day 8. Gemcitabine was omitted on day 8 in case of neutrophils <0.5 × 10 l−1, platelets <50 × 10 l−1 or grade 4 nonhaematologic toxicity.

There is, however, some consensus that schedules using cisplatin 100 mg m−2 on day 1 of a 28 day cycle are less able to deliver the full dose of gemcitabine due to frequent dose omissions and reductions for haematological toxicity on day 15 (Abratt et al, 1998).

In one patient at this dose level, however, therapy had to be stopped on day 8 due to toxicity.

The most important toxicity was myelosuppression, which occurred almost always on day 8 (docetaxel nadir).

The gemcitabine and cisplatin doses were reduced for toxicity on the day of treatment as follows: 75% of the drug dosage was given to patients with an absolute neutrophil count of 500 900 mm−3 or with a platelet count of 50 000–74 000 mm−3, and doses were reduced 50% if patients had an absolute neutrophil count of less than 500 mm−3 or a platelet count of 50 000 mm−3.

All toxicities improved on day 28.

This regimen was well tolerated, with most haematological toxicities occurring on day 15, the planned rest day.