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Data are limited with regard to toxicity of therapy in older patients in these settings.
Analyses of the effect of age on overall survival benefits and/or toxicity of therapy were extracted.
As long-term outcomes in lupus nephritis improve, the toxicity of therapy and risk of relapse become increasingly important determinants of the choice of therapeutic agents.
When evaluating the toxicity of therapy, the NE regimen in this study was considered to be well tolerated.
Interferon alfa had no significant influence on survival when combined with adjuvant 5-FU, but increased the toxicity of therapy substantially.
Owing to the palliative nature of second-line therapy in NSCLC and its relatively modest effect on survival, minimising the toxicity of therapy is an important consideration.
Similar(49)
Thus, DNA damage causes the disease, is used to treat the disease, and is responsible for the toxicity of therapies for the disease.
Elderly breast cancer patients are often underrepresented in clinical trials because of higher rates of underlying comorbidities, concerns about toxicity of therapies, including cardiotoxicity, risks of mortality, and other reasons [ 7– 9].
The possibility to develop cancer therapies based on the activation of death receptors has been attractive since their discovery, however toxicity of therapies targeting TNF and CD95 have greatly reduced the initial enthusiasm.
The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases.
See related research by Palomino-Morales et al., http://arthritis-research.com/content/12/2/R71 With the availability of increased information about the role of common genetic polymorphisms in disease susceptibility, response to therapy and toxicity of therapies, the prospect of increasingly personalized medicine is becoming a reality.
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CEO of Professional Science Editing for Scientists @ prosciediting.com