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Acute aquatic toxicity laboratory experiments were performed to evaluate aquatic hazards and were conducted according to standard OECD test guidelines with rainbow trout (Oncorhynchus mykiss), water fleas (Daphnia magna) and algae (Pseudokirchneriella subcapitata).
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This chapter reviews the laws and regulations that pertain to present-day animal care and use in the toxicity testing laboratory.
Body weight is often used as an indicator of toxicity in laboratory animals.
The studied plants showed no overt toxicity in laboratory mice.
Species-dependent metabolism prevents an accurate prediction of toxicity with laboratory animals (e.g. rodents, fish).
Worst-grade toxicity of laboratory values was recorded by the patient and by the cycle.
Toxicity of laboratory results was assessed based on the WHO Toxicity Grading Scale for Determining the Severity of Adverse Events.
2,3,7,8-Tetrachlorodibenzo 2,3,7,8-Tetrachlorodibenzorelated environmental contaminants are aryl hydrocarbon receptor (AhR) ligands that exert reproductive and developmental toxicity in laboratory animals.
MEHP has been associated with developmental reproductive toxicity in laboratory studies (Oishi 1986; Park et al. 2002; Sjoberg et al. 1986).
The Ah receptor is cited as an example of a protein-small molecule interaction associated with extreme acute toxicity in laboratory animals.
Flame retardants have been shown to possess a wide spectrum of toxicity in laboratory animals, and they are present in every level of the food chain.
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