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Fortunately, antidotal therapy is available for acetaminophen toxicity in the form of N-acetylcysteine (NAC).
Drug-induced renal toxicity in the form of inflammation is a common finding [28], some of which are dose related.
Severe toxicity in the form of reduced growth and plant death was recorded at 12.5 mmol of each chelator.
Thus avoiding the use of hydroxylpropyl β-cyclodextrin which would finally cause the rapid drug clearance from the blood and dose-limiting toxicity in the form of hemolytic anemia.
These landfills bleed toxicity in the form of heavy metals into underground water and release heat-trapping greenhouse gases like methane (23 times stronger at retaining heat than CO2) into the atmosphere.
Early broad spectrum MMP inhibitors directed towards the zinc region of the catalytic domain (inhibitors exploiting the hydroxamate function as a zinc-binding group) have been ineffective because of their dose limiting toxicity in the form of musculoskeletal syndrome (MSS), characterised by joint stiffness and inflammation [9].
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Dose limiting toxicities in the form of gastrointestinal disorders were experienced for the highest dose hence the dose recommended for phase II trial was 20 mg/m/day.
Dose-limiting toxicities in the form of mucositis, diarrhoea and vomiting were observed at doses of 6 mg/m and above.
The maximum tolerated dose was established at 3700 mg m−2; dose-limiting toxicities in the form of urinary incontinence, visual disturbance, and anxiety were observed at the highest dose level (4900 mg m−2).
It should be noted that the urine profile measured by NMR not only distinguished between the subgroups, but also gave a measure of the degree of toxicity in the forms of the direction and the Euclidean distance of a particular group from the control group.
Cardiac dose-limiting toxicity (DLT) in the form of atrial fibrillation did occur in 1 of 6 patients treated with melphalan 280 mg/m280
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