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Even with multiple mechanisms leading to toxicity, each of which coming with a different pharmacophore, the true actives are expected to be more like each other than random compounds and cross prediction should be easier.
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Namely, the toxicity of zinc and copper was eight times higher than the toxicity of each of these metals taken separately [29].
Given the high correlation among the five BTEX compounds (r > 0.75) and because the relative fetal toxicity of each of them is not well known (Agency for Toxic Substances and Disease Registry 2004), we used the LUR estimate of the sum of the five compounds to assess the relationship between BTEX exposure and birth weight.
The overall assumption under dose additivity is that the toxicity of each component of the mixture behaves as a known dilution of a reference chemical selected as the index compound (U.S. EPA 2000).
We wished to compare the toxicity of each of five overproduced E. coli chromosomal toxins.
Dose modification for toxicity for each of the drugs was pre-specified in the protocol.
The differences in toxicity of each of the individual trichothecenes warrants surveillance of the (co- occurrence of these myco- occurrenceheir profucers.
The combinatorial strategies in cancer therapies can provide more synergistic tumor inhibition and less systemic toxicity than each of the monotherapeutic regimens alone.
Utility decrements for toxicities were generated by subtracting the utility for the base case (no change) from the utility of the toxicity state (each of which was described in association with no change).
We therefore relied upon knowledge of the exposure pathways, bioavailability and toxicity for each of these chemicals to judge regulation and legislation in different states with respect to the extent to which they could reduce burden of disease.
When considering the effect of genetic reduction in autophagy has on CQ-mediated toxicity in each of these cell lines in combination with the observed effect of RAS on autophagy in each cell line, the expected effect of RAS on CQ toxicity if it were solely acting on autophagy does not match the observed effect of RAS on CQ-mediated toxicity in these cell lines (summarized in Fig. 7G).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com