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For PPPs and biocides, the toxicity criterion presents challenges because they are toxic chemicals, which, by definition, are produced and used for the control of target species (pests).
The reason is that even if the toxicity criterion is not fulfilled, the respective compound may show toxic effects under extreme conditions.
bTAQUA: substances fulfil the toxicity criterion for water organisms laid down under point 3.7.2.3 of Annex II to Regulation (EC) No 1107/2009 [[1]], in addition to the P or the B criterion.
dActive substances that fulfil the toxicity criterion for water organisms laid down under point 3.7.2.3 of Annex II to Regulation (EC) No 1107/2009 in addition to the P or the B criterion as defined under points 3.7.2.1 and 3.7.2.1 of the same Annex II [[1]], and active substances that contain a significant proportion of non-active isomers; human health criteria may apply additionally.
The first escalation round, from 200 to 400 mg b.i.d., was an exception to these rules as it could occur regardless of the pShift value, as long as the toxicity criterion was not met.
The ranking of the drugs are performed by ordering the drugs according to the centers of the closest to the farthest from the center of the desired extreme case (such as the completely fragmented state for toxicity criterion).
Similar(54)
Toxic effects were graded with National Cancer Institute common toxicity criteria, version 3.0 [ 18].
The toxicity criteria of Art.
Toxicity was graded retrospectively using National Cancer Institute common toxicity criteria version 4.0.
Adverse events were graded using the National Cancer Institute toxicity criteria (V3.0).
CW pain was assessed using the Common Toxicity Criteria for pain.
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